Is there any way to pipe e-mail into a script (perl script) via siteworx?
No, not via SiteWorx, but it can be set up manually by the server admin by creating file like this:
/home/<user>/var/<domain>/mail/.qmail-username
and put in that file:
|/path/to/perl/script
That would set up the pipe for a username@<domain> e-mail address.
Paul