Why does this happen?
My server load went way up because of something with SMTP. I was able to shut down SMTP via NodeWorx, which helped make NodeWorx more response of the load dropped.
Looking at the Queue I noticed an email for one account on my server with a -1 in the day in queue column. Also weird was when I viewed the message it was an email from another account on my server (two unrelated accounts).
After deleting that message the serer is now running normal again.
So not sure if I got a bunch of spam or something and it screwed up the queue and that one message was causing problems or what.