How to get Interworx authenticate when sending email?

I have Interworx set up with nodeworx users email to info@mydom.se - this emailaccount is on a windows-webbhosting server (same subnet as Interworx).
Problem is when Interworx sends an email to peterh@mydom.se it can’t be delivered:

Connected to 190.18.19.20 but sender was rejected.
Remote host said: 551 This mail server requires authentication before sending mail from a locally hosted domain. Please reconfigure your mail client to authenticate before sending mail.

So Interworx can’t send to peterh@mydom.se but to info@mydom.se??
I set up backup-jobs with email-notification to myself, that’s when I get this strange error.

Hi pingu,

Is the mydom.se mail server 190.18.19.20? That seems like a message that would happen if the 190.18.19.20 mail server did not handle mail for the mydom.se domain, and thought you were trying to relay.

Paul

No, it is the mail server for mydom.se, no relaying.
And how come Interworx can send to info@mydom.se but not to peterh@mydom.se?